Healthy Living Forum
What is Metronomic Fractionated Chemotherapy combined with Cancer pH Manipulation?
While a number of effective chemotherapies are available, tumors inevitably evolve resistance to these drugs ultimately resulting in treatment failure and cancer progression. Causes for chemotherapy failure in cancer treatment include poor blood supply to the tumor, low tumor oxygen concentrations, and resistance to drug-induced toxicity through up-regulated metabolic pathways or DNA repair mechanisms.
Unless a cytotoxic therapy eradicates all cancer cells, its application to a tumor population also produces evolutionary selection forces that will select for cells that are adapted to the therapy and, thus, fittest to these conditions. In fact, this mechanism has been used to produce many chemo-resistant cancer cell lines.
A fundamental principle of chemotherapy is to use drugs that are more toxic to tumor cells than to healthy cells, the preferred target being the cancer cell replication mechanisms, as many tumors replicate faster than the host. Unfortunately, tumors are not homogenously proliferative. Typically, only its outer rim is composed of replicating cells, while much of its inner mass consists of cells in quiescent or even dying states.
Thus, the cells on the outer rim of the tumor are the most readily targeted by chemotherapy due to their proximity to blood vessels and their fast growth. This region of the tumor is thus environmentally sensitive and is mostly composed of chemotherapy-sensitive cells, even though some resistant cells may be present.
The inner regions of a solid tumor are often hypoxic (low oxygen concentrations) and acidic due to anaerobic glucose metabolism (feeding rapidly on sugar), which leads to quiescence and increased chemo-resistance. The increasing distance from blood supply reduces the concentration of chemotherapy in these regions of tumor, conferring a second cause for resistance.
Metronomic Fractionated Chemotherapy
The definition of metronomic fractionated chemotherapy varies, but generally it refers to repetitive, low doses of chemotherapy drugs designed to minimize toxicity and target the endothelium (which will form new blood vessels) or tumor stroma (abnormal connective tissue that feeds the cancer) as opposed to targeting the tumor. The metronomic approach was initially proposed and tested in animal models by Dr. Timothy Browder in Dr. Judah Folkman's lab at Harvard Medical School. In the studies, standard maximum-tolerated dose (MTD) chemotherapy regimens caused cell death of endothelial cells in the blood vessels feeding to the tumor first, followed by tumor cells. But the long breaks needed between the MTD regimens allowed the damaged blood vessels, and thus the tumor, to recover.
But significantly lower doses given more frequently on a prolonged schedule proved to be far more effective, including complete tumor regressions, even in mice that were resistant to the same drug when used in a standard MTD regimen. Since then, several research groups have confirmed these findings. Therefore, the advantages of metronomic fractionated chemotherapy appear to be lower toxicity, inhibition of angiogenesis (inhibits development of blood vessels that will feed the tumor), and possibly less resistance due to more frequent administration.
Cancer pH Manipulation Therapy
Metronomic fractionated chemotherapy may be an effective method for treating the outer rim of the tumor, with minimal toxicity, but what about the inner mass, that is anaerobic, hypoxic, and lacking blood supply? Using a technique called Cancer pH Manipulation Therapy, in combination with metronomic fractionated chemotherapy, it may be possible to eradicate both the inner and outer core of the tumors. As stated above, the inner core of tumors relies on glucose for energy. The end product of glycolysis (the method for processing glucose into energy) is lactic acid. Tumor cells in the inner core produce a large amount of lactic acid, which then must be pumped out of the cell. Pumping acid out of the cell serves two purposes:
Using a cocktail of oral drugs, it is possible to halt the cancer cells’ ability to pump out its own acid. This technique will cause the “inner core” cancer cells to die due to severe acidosis. Combining Cancer pH Manipulation with Metronomic Fractionated Chemotherapy we may be able to eradicate not only the rapidly dividing outer core cells, but the inner core cancer stem cells as well.
I am experiencing unexplained weight gain. What can I do to stop it?
It sounds like you have what we refer to as “ intestinal dysbiosis and small bowel bacterial overgrowth”. It’s not so far fetched that you lose weight with certain antibiotics…we have different bacteria in our gut: Firmicutes and bacteroidetes included which control the level of caloric extraction from the food you eat and when altered in proportion can give you an easier weight loss. There are other issues surrounding weight gain; toxins in the fat, a liver that doesn’t metabolize fat for burning as well as it used to and specific nutrient deficiencies. We use a stool kit (in the privacy of your own bathroom) to test the internal environment of your GI tract; bacteria (good and bad), yeast, parasites, digestive status, immune status etc. for the larger picture of what’s going on inside. Then we agree on treatment you will do and you get better.
Are Genetically Modified Foods Harmful to Our Health?
By David Blyweiss, MD
The Palm Beach Post recently ran the story, “FDA to Consider Genetically Engineered Salmon” . There are a few points for completeness sake the reporter was remiss in leaving out of this article. This is not the first genetically modified food. We began genetically engineering food in the middle of the last century, beginning with what we presently call wheat. From there we progressed to corn to prevent certain pests from getting into the crop. The list has grown inclusively to other critical heirloom seeds for vegetables and fruits. The common denominator in each and every one of these " foods" is the far reaching down the road negative effects that they have had us. It sometimes takes a generation or two to appreciate it though.
The new higher content gluten in "wheat" has been at least partially responsible for the increase in autoimmune disease since we cannot fully digest it (although drugs are being formulated to correct this) and the glycemic index of two pieces of our new bread is higher than most candy bars, contributing to our epidemic of obesity and diabetes.
The rootworm beetle that GMO corn was made for( to protect itself from) has beaten the patent and is developing resistance, returning to its natural element; and yes when the corn spreads as it naturally will, the company that holds the patent can keep the local farmers whose property borders the "frankenfood" site in court long enough to bankrupt them. And we didn't even begin to talk about high fructose corn syrup or on the fruits and veggies no longer able to reproduce on their own because they are seedless.
We don't have to go far back in our cultural memory to find a quote that opens our eyes to the truth of what will certainly and eventually happen. These fish will escape to the wild with repercussions unknown, from Steven Spielberg and "Jurassic Park"…" nature finds a way", it always finds a way.
And placing an extra gene from an eel like fish to keep the salmon from freezing?? The salmon have already figured that out on their own, they produce EPA/DHA fish oil in the deep cold water to keep themselves limber…that's one of the reasons we eat them.
How to Survive the Holidays While Maintaining a Gluten Free Diet
Is it possible to stay gluten-free through all the holiday parties and family gatherings this season? It is but it can be a challenge for anyone. If you've got celiac disease, your immune system treats gluten like a toxin. It was once a rare disorder, but now celiac disease is four times more common today than it was five decades ago.
Even if you don't suffer from the disease itself, many are still sensitive to gluten — especially if you suffer from:
Eating holiday cookies or other seasonal favorites that contain gluten can actually damage the intestines of those with celiac. Even if you haven't tested positive for celiac, you still might not be out of the woods. It turns out that 30 million Americans have nonceliac gluten intolerance. That's 1 in every 10 of us!
The symptoms can be the same as celiac, but gluten sensitivity doesn't damage the intestine. If you do discover that gluten isn't your friend, don't run out and stock up on gluten-free pizza and brownie mix. Going gluten-free doesn't necessarily equal healthy at any time of the year. In fact, if you start to rely on all those trendy gluten-free ultra-processed packaged foods, you just might end up with nutritional deficiencies.
Here's what I tell my patients who can't eat gluten: Skip the gluten-free goodies that crop up at holiday party trays. Instead, focus on fresh fruits, vegetables, lean protein, dairy and gluten-free grains like non-contaminated oats, amaranth and quinoa.
If you do opt for some pre-seasoned or packaged foods, read the ingredient label carefully to make sure it doesn't contain any gluten. Familiarize yourself with ingredients such as natural flavors, monosodium glutamate, modified food starch, malt, seasoning and hydrolyzed vegetable protein that contain gluten. Also, don't skip your comprehensive multivitamin and vitamin B complex to make up for the nutrients you would normally get from whole grains.
If you have celiac disease or gluten sensitivity, keeping your diet focused around fresh, naturally gluten-free foods and sticking to holiday foods cooked from scratch as often as possible is the best way to avoid exposure. You'll not only discover a whole new world of delicious foods, and you will be able to enjoy the holidays as much as anyone else.